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dase. CONCLUSIONS Human IAV can infect the heart and cardiac specific conduction system, which may contribute to cardiac complications and premature death. TRANSLATIONAL PERSPECTIVE Influenza A virus (IAV) can infect several cell types in the mouse heart. Human IAV with the highest pathogenicity replicate more rapidly in mouse cardiomyocyte cultures and induce a cardiac pro-inflammatory state, which correlates with underlying molecular changes and mitochondrial dysfunction in human induced pluripotent stem cells-derived cardiomyocytes.