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OBJECTIVE To determine the relationship between skin moisture and the incidence of medical devices related to pressure injury (MDRPI). METHOD This was a prospective study in an intensive care unit. Measurement of changes in skin moisture is measured every two days until thirteenth. The skin moisture status between no MDRPI and presence of MDRPI analyzed using independent t-test. RESULT The independent t-test confirmed no difference of skin moisture between no MDRPI group (the range of moisture 28.81±2.68 to 32.38±5.44) and presence MDRPI