https://www.selleckchem.com/pr....oducts/gsk2636771.ht
Anemic stress induces stress erythropoiesis, which rapidly generates new erythrocytes to restore tissue oxygenation. Stress erythropoiesis is best understood in mice where it is extramedullary occurring primarily in the spleen. However, both human and mouse stress erythropoiesis utilize signals and progenitor cells that are distinct from steady state erythropoiesis. Immature stress erythroid progenitors (SEPs) are derived from short-term hematopoietic stem cells (ST-HSCs). Although the SEPs are capable of self-renewal, they are eryth
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