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Adult ADHD and Comorbid Disorders Many adults suffering from ADHD also suffer from comorbid conditions such as major depressive disorder (Kessler and colleagues 2006). Many sufferers do not respond to depression medications and may benefit from psychotherapy. Treatments that are most effective in reducing core symptoms of ADHD seem to boost and regulate levels of certain neurotransmitters in the brain. Stimulants such as methylphenidate and amphetamine are frequently prescribed. Medicines Adults can take a variety of medications that are used for ADHD in