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Moreover, we observed transfer of heme from the core to the HRMs and equilibration of heme between the core and HRMs. We therefore propose an Fe3+-heme transfer model in which HRM-bound heme is readily transferred to the catalytic site for degradation to facilitate turnover, but can also equilibrate between the sites to maintain heme homeostasis. Published under license by The American Society for Biochemistry and Molecular Biology, Inc.Over the last several years it has become clear that higher order assemblies on membranes, exemplified