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Grinding increased the fatigue failure load, number of cycles to failure and survival rates of the second-generation zirconia statistically (control 1373.33 N grinding 620 N). Thus, clinical adjustments with diamond burs damage the fatigue behavior of adhesively cemented third-generation zirconia. The successful development of cartilage repair treatments for the knee requires understanding of the biomechanical environment within the joint. Computational finite element models play an important role in non-invasively understanding knee me