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How Does Medication For ADHD Work? Stimulants are among the most frequently prescribed ADHD drugs. They increase the levels of brain chemicals, called dopamine and norepinephrine. These include methylphenidate, amphetamines and dextroamphetamines (Adderall) and lisdexafetamine, (Vyvanse). Doctors typically prescribe these in long-release versions that last between six and eight hours or more, which reduces fluctuations and downs when the medication gets rid of. This may reduce symptoms for most people. Stimulants Many people manage ADHD with medicat