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In this research, we now have used an exosome-functionalized doxorubicin-loaded biodegradable nanocement (NC)-based carrier along side a Cissus quadrangularis (CQ) extract-laden antioxidant herbal membrane layer for simultaneously managing the periosteum as well as bone tissue formation into the tumor resection model of osteosarcoma. We initially evaluated the efficacy of scaffolds for in vitro mineralization and bone tissue development. To examine the