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age and adherence, implementation of the TB/HIV collaboration activity, and early initiation of ART to reduce opportunistic infections. Determining the degree of health-related quality of life (HRQoL) and associated factors in human immunodeficiency virus (HIV)-positive people is of great importance. The aim of this study was to assess the HRQoL and associated factors among HIV-infected patients who were on highly active antiretroviral therapy (HAART) at Ambo General Hospital. A study with a cross-sectional design was conducted on 296