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The RoAD score (ranging from 0 to 8) derived from the training set (n=1225), was based on demographic (age), clinical baseline prognostic factors (disease duration, EDSS) and 1-year predictors of treatment response (number of relapses, presence of gadolinium enhancement and new T2 lesions). The best cut-off score for discriminating patients at higher risk of reaching the disability milestone was ≥4. When applied to the validation set (n=296), patients with a RoAD score ≥4 had an approximately 4-fold increased risk for