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5 kPa and a PLT value of ≤110 × 10 /L indicated HRVs, with accurate rates of 82.35%, and 10.63% of patients can avoid additional endoscopy screening. Moreover, antiviral therapy had no significant effect on the accuracy and rates saved from further endoscopy screening, when comparing patients with or without antiviral therapies (all values 0.05). The combination of LS (14.5 kPa) measured by 2D-SWE and PLT (110 × 10 /L) can predict HRVs accurately in compensated hepatitis B-related cirrhotic patients without significant interference