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05). We also did not find any significant association between the risk of the cancer and mir-499 polymorphisms in the recessive (Odds ratio [OR] 6.60; 95% confidence interval [CI] 0.77-56.74; = 0.11) and dominant (OR 1; 95% CI 0.37-2.74; = 1) inheritance models even after adjustment for smoking. The results of the present study indicated that the polymorphisms of mir-499 are not associated with the risk of oral and oropharyngeal SCC in Iranian population. However, further large scale studies are needed to validate our findings. The r