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ADHD Treatment For Adults The stimulants methylphenidate and amphetamine help boost levels of certain brain chemicals. Nonstimulants, such as atomoxetine and antidepressants, operate more slowly than stimulants but they can be beneficial too. Complicating conditions often affect the response to ADHD medication. Doctors should treat the most severe symptoms of any comorbid disorder first, and then monitor whether the ADHD symptoms improv