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ADHD Treatment For Adults Stimulants like methylphenidate and amphetamine increase the levels of certain brain chemicals. Nonstimulants, such as atomoxetine and antidepressants, operate more slowly than stimulants but can also be beneficial. The comorbidity of conditions can affect the response to ADHD medications. The most severe symptoms from any comorbid condition should be treated first. Then, the physician must be able to determine i