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Our research disclosed that miR-34a induces myofibroblast differentiation from renal fibroblasts. More over, the miR-34a-induced upregulation of α-SMA ended up being independent of the TGF-β/SMAD signaling path. In conclusion, our research indicated that the p53/miR-34a axis encourages the development of renal fibrosis.Providing historic data on riparian plant biodiversity and physico-chemical parameters of stream water in Mediterranean mountains helps gauge the ramifica