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Scenarios of varying data sparsity and residual error are considered. The goodness-of-fit test correctly identified misspecified parametric models with high power for relevant scenarios. The case study provides proof-of-concept of the feasibility of the proposed approach, which is envisioned to be beneficial for applications that lack well-founded covariate models.Recombination between HLA-B*15010101 and HLA-B*54010101, HLA-B*55020101 or HLA-B*59010101 resulted the novel allele of HLA-B*1586.Building a covariate model is a crucial task

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