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Results TOTPAR4 scores showed that FDC 25/25 was noninferior (P less then 0.0001, delta = 1.5) and FDC 50/50 was superior (P less then 0.0001) to the individual components. All secondary efficacy measures supported these results. The safety profile of FDC 25/25 and FDC 50/50 was consistent with the known safety profile of D50 and T50 monotherapies, with no unexpected safety findings observed. Conclusions Tramadol/diclofenac FDC 25/25 and FDC 50/50 provide superior analgesia for acute pain after third molar extraction than either of the in
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