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New therapeutic options for patients with Crohn's disease (CD) with perianal lesions failing anti-tumor necrosis factor (TNF) agents are needed. We aimed to assess the effectiveness of ustekinumab in perianal CD (pCD) and predictors of clinical success in a real-life multicenter cohort. We conducted a national multicenter retrospective cohort study in patients with either active or inactive pCD who received ustekinumab. In patients with active pCD at treatment initiation, the success of ustekinumab was defined by clinical success at 6 mo

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Female ADHD Symptoms ADHD is often misdiagnosed in girls since it manifests differently than boys. Adult women may have the inattentive type of ADHD or combined inattentive and hyperactive-impulsive symptoms. They also tend to develop unhealthy coping strategies, such as excessive alcohol consumption and drug abuse, which mask ADHD symptoms and delay a proper diagnosis. Coexisting conditions, such as anxiety and depression, are also common in these individuals. Attention! Women who are