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TECHNIQUES utilizing combined evaluation of genome-wide gene appearance and methylation profile from 40 matched normal-tumor pairs of OSCC specimens, we found a couple of retinoid signaling related genetics are generally hypermethylated and downregulated in OSCC client examples, including alcoholic beverages dehydrogenase, iron containing 1 (ADHFE1) and aldehyde dehydrogenase 1 family members, member A2 (ALDH1A2), that are the important rate-limiting enzymes in synthes
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