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Nevertheless, whether or otherwise not oliceridine really displays an ideal pharmacological profile as an analgesic has not yet been totally clarified in pet researches. This study examined the pharmacological profile of oliceridine in cells and creatures. Oliceridine (10 μM) did not create any μ-opioid receptor internalization in cells although it enhanced impedance, which reflects the activation of Gi necessary protein utilizing the CellKey™ system, and inhibited
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