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Risk score models comprising the sum of the points stratified patients into three risk groups (0, 1, and 2-3; P 0.001 for CSS and OS) with respective c-indices of 0.843 and 0.820. SII 677 and ≥ cT3 were independently associated with muscle invasion. A model based on these variables predicted muscle invasion with AUC of 0.804. Preoperative SII is significantly associated with worse survival outcomes and muscle invasion in patients with non-metastatic UTUC. Our preoperative predictive models may serve as a guide to