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770; 95% CI 1.687-4.548, P0.100 mg/dL more frequently had major bleeding than those without (log-rank test, P less then 0.001). ORBIT-i score had the highest C-index of 0.711 (95% CI, 0.654-0.769) compared with the ORBIT and HAS-BLED scores. CONCLUSIONS Persistent systemic inflammation was associated with major bleeding risk. ORBIT-i score had a higher discriminative performance compared with the conventional bleeding risk scores.Objective Although acute coronary syndrome (ACS) is an uncommon entity in young patients, it constitutes an im