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54, 95% CI 1.71-3.77; p0.001) were independently associated with clinically relevant bleeding events, while age 85years (adj.HR 2.22, 95% CI 1.14-4.30; p=0.018) was independently associated with major bleeding events (BARC types 3 or 5). Patients with a clinically relevant bleeding event had a higher rate of MACE at 1year (adj.HR 2.04, 95% CI 1.24-3.38; p=0.005), with a particularly strong effect on stroke (adj.HR 5.55, 95% CI 2.04-15.06; p0.001). Clinically relevant bleeding events were observed in one out of five elderly p