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While the intrinsic complexity of natural productbased drug discoveries requires highly integrated interdisciplinary approaches, scientific and technological advances and research trends clearly show that natural products will be among the most important new drug sources in the future. In this review, an overview of the studies conducted for the discovery of multitargeted drug molecules in the rational treatment of gynecological cancers is presented. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.BACKGROUND C