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Lumbar puncture (LP) and intrathecal chemotherapy (IT CT) are common procedures and treatment options for hematologic patients. Although they can also be used in thrombocytopenic patients, there is no consensus on the safe cutoff value of platelet counts for LP and IT CT practices. This research aimed to determine the safety of LP and IT CT administration in thrombocytopenic patients using different cutoff platelet values. One hundred and fifty-two adult patients who had LP indications were evaluated. Among them, 42 patients received IT