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Stimulants Are the Most Effective ADHD Medication For Adults Stimulants are among the most commonly prescribed prescription medications that healthcare professionals utilize to treat ADHD in adults. They help by increasing the levels of neurotransmitters (chemicals) in your brain. This improves attention and decreases impulsivity. Antidepressants, such as Strattera (atomoxetine) and Wellbutrin/Zyban and Bupropion (bupropion) are also able to help control ADHD. They boost the levels of norepinephrine in your brain. Stimulants Stimulants are the m