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Eligible studies stating on diagnostic yield of considerable systemic staging, including pre-treatment whole-body 18F-fluoro-deoxy-glocose positron emission tomography with or without calculated tomography, in immuno-competent grownups with PCNSL were identified through organized literature search. Diagnostic yield ended up being thought as the proportion of patients with abnormal test results beyond your neuraxis that resulted in detection of concordant systemic high-