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The MSSI scores in the patients were correlated with serum levels of IL-6 (r=0.60, p0.001) and TNF-α (r=0.45, p0.001). FD was associated with elevated serum levels of IL-6 and TNF-α in this cohort. The FD patients treated with ERT, particularly, women, exhibited higher levels of serum IL-6 and TNF-α than those not treated with ERT; the serum IL-6 and TNF-α levels were correlated with the MSSI scores reflecting greater disease burden. FD was associated with elevated serum levels of IL-6 and TNF-α in this cohort. The FD patients