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ADHD Medications - Stimulant Or Non Stimulant? Stimulant drugs are the most popular ADHD medication, as they're the most studied and have the fastest-acting effects. However, they're not for everyone. boost the communication between nerves and brain regions to reduce ADHD symptoms. These medications can also cause side-effects like a change in blood pressure or heart rate, as well as a loss of appetite. Stimulants The most commonly used