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ADHD Treatment For Adults Stimulants such as methylphenidate, amphetamine and other brain chemicals can increase levels. Nonstimulants, such as antidepressants and atomoxetine, work slower than stimulants but they can be beneficial too. The comorbidity of conditions can affect the response to ADHD medication. Physicians should address the most severe symptoms of any comorbid disorder first, and then examine whether the ADHD symptoms