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Additional target annotations were frequently identified for competitive inhibitors, but were rare for allosteric inhibitors. As a part of this study, our collection of kinase inhibitors and the associated information are made freely available to enable further assessment of chemical modifications that distinguish similar kinase inhibitors with distinct mechanisms of action.The paper focuses on the scaffold hopping-based discovery and characterization of novel nicotinic alpha 7 receptor positive modulator (α7 nAChR PAM) ligands around t

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In terms of relative contribution, Ca, Fe, and Mg content in soils and Zn, K, and Ca content in leaves contribute relatively largely to a single fruit weight, Mn, Fe, and Mg content in soils and the N content in leaves contribute relatively largely to the soluble solid content, and the P, Ca, N, Mg, and Fe in leaves contribute relatively largely to the titratable acid content of loquat. The established artificial neural network prediction models can improve the quality of loquat fruit by optimizing the content of mineral elements in soi