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Background Understanding how frailty affects health-related quality of life (HRQOL) in those with chronic kidney disease (CKD) could assist in the development of management strategies to improve outcomes for this vulnerable patient group. This study aimed to evaluate the relationship between frailty and HRQOL in patients with CKD Stages 4 and 5 (G4-5) and those established on haemodialysis (G5D). Methods Ninety participants with dialysis-dependent chronic kidney disease (CKD G4-5D) were recruited between December 2016 and December 2017.