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Urinary [TIMP-2]*[IGFBP7] serves as a sensitive and specific biomarker in the diagnosis of PRAKI. Urinary [TIMP-2]*[IGFBP7] serves as a sensitive and specific biomarker in the diagnosis of PRAKI.We evaluated the associations amongst fine particulate matter (PM2.5 less then 12, 12-14, and ≥15 μg/m3) and nitrogen dioxide (NO2 less then 26, 26-29, and ≥30 ppb) and abruption in prospective cohort of 685,908 pregnancies in New York City (2008-2014). In co-pollutant analyses these associations were examined using distributed lag non-linear mode