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An esophagectomy is the key component of curative esophageal cancer treatment. Textbook outcome is a composite measure describing an optimal perioperative course, including parameters regarding a radical resection with at least 15 lymph nodes and an uncomplicated postoperative course without hospital readmission. This study assessed clinicopathological predictors for textbook outcome and the association of textbook outcome with survival in two tertiary referral centers. All esophageal cancer patients who underwent an esophagectomy with g