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Multiple myeloma (MM) in Hispanics has never been studied. We therefore sought to determine the clinical characteristics and overall survival in MM of Hispanics compared to non-Hispanic whites (NHW) and non-Hispanic blacks (NH. A single-center analysis of 939 patients diagnosed with MM from 2000 to 2017 with a large representation of NHB (n= 489), Hispanics (n= 281), and NHW (n= 169) was conducted to evaluate outcomes and disease characteristics. We used the Connect MM Registry, a large US multicenter prospective observational study