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, ranging broadly from hydrogen bond to dipole-dipole/quadrupole interactions, electrostatic interaction, acid-base interaction, coordination, and electronic interactions. We scrutinize the unique properties and functions of adsorption and separation, catalysis, energy transformation and storage, and proton and metal ion transport by disclosing functional design schemes and interface-function correlations. We predict the fundamental key issues to be addressed and show future directions in designing artificial pores to target at ultimate