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However, the induced depressive-like behaviors following DM administration may be sexually dependent. Copyright© 2019 Iranian Neuroscience Society.Introduction Neurogenesis mainly occurs in the hippocampus that is sensitive to radiation. More histological changes are reported at higher doses of radiation, while low dose radiation causes cognitive dysfunction in adult mammals. In the present study, we tried to correlate the Endoplasmic Reticulum (ER) stress-mediated hippocampus dysfunction after whole-body gamma radiation of mice. Meth