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We found that patients who started PN during COVID-19 were more malnourished with lower body mass index and higher proportion of Subjective Global Assessment B/C scores (52 [92.9%] vs 36 [73.5%], P .005). The proportion of patients who achieved target energy amounts within 5 days was similar in both groups. Protein prescription was 1 g/kg/day in both groups, though there was a trend of higher protein prescription during COVID-19. Complications were similar in both groups. Our study demonstrates that minimal contact with effecti