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Strong consideration should be given to the placement of SSCs on primary molars in patients with early childhood caries under general anesthesia. Placement of primary molar SSCs during initial treatment under general anesthesia may reduce the need for additional treatment in the future.Purpose Casein phosphopeptide amorphous calcium phosphate fluoride varnish (commercially available as MI Varnish®) is a promising minimally invasive remineralizing agent. The purpose of this study was to compare the effectiveness of intensive application of