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On the other hand, anti-pneumococcal vaccination of 13 serotypes showed results close to statistical significance (OR=0.4; 95% CI 0.170-1,006). Obesity and the use of ARA-2 increases the risk of COVID-19. Scientific knowledge about factors associated with COVID-19 should be expanded. The authors consider that the present research raises the need further investigate the role of vaccines in this infection and their possible heterologous properties. Obesity and the use of ARA-2 increases the risk of COVID-19. Scientific knowledge about facto