https://www.selleckchem.com/pr....oducts/ar-c155858.ht
DTX therapy endorsed Ca2+-controlled autophagy as well as SIDT2 appearance, resulting in lysosomal destruction associated with miR-25 within U937 tissues. Downregulation associated with miR-25 elevated NOX4 mRNA balance and also proteins term. NOX4-stimulated ROS age group resulted in JNK-mediated phosphorylation regarding cytosolic HuR with Ser221, thus increasing TNF-α health proteins term through backing TNF-α mRNA. Therefore, DTX caused TNF-α-dependent loss of life throughout U937 tissues. Destruction associated with HuR utilizin
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