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Pregnancy is a critical period keenly regulated by both maternal and foetal factors and a shift in these factors could result in severe complications manifesting in foetal and adult life. However, maternal hypothyroidism before and/or during pregnancy is a critical factor. This study investigated the effect of maternal hypothyroidism on glucose tolerance and thyroid function in male and female offspring. Fifteen adult female Wistar rats were divided intothree groups Group 1 (sham-control), Group 2 (thyrodectomized) and Group 3 (thyroid