https://www.selleckchem.com/pr....oducts/stat3-in-1.ht
Using the Ishak scoring system, we found that the fibrotic burden was significantly lower in mPTD-BMP-7 treated mice than in control mice (all P less then 0.001). Treatment with mPTD-BMP-7 protected tight junctions between hepatocytes and reduced extracellular matrix protein levels. It also significantly decreased mRNA levels of collagen 1A, smooth muscle α-actin, and connective tissue growth factor compared with that in control mice (all P less then 0.001). Collectively, out results indicate that mPTD-BMP-7, a prodrug formulation of
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