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In addition, an intimate cross-talk of mitochondria with energy signalling pathways, like those represented by Target of Rapamycin and Sucrose non-fermenting1-related protein kinase 1, can be envisaged. This review discusses available evidence on the role of mitochondria in shaping plant growth and stress responses through different signalling pathways. To evaluate the safety and efficacy of abatacept treatment for refractory juvenile localized scleroderma (jLS) in a retrospective study. A multicentre cohort study was performed to evalu