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ROS-activatable prodrug 1 and a negative control struggling to launch free drug had been synthesized and examined for peroxide-mediated activation. Prodrug 1 blocks task of 147 by its incapacity to undergo metabolic oxidation by ER-resident cytochrome P450 enzymes such Cyp1A2, probed straight here for the first time. Biological assessment of ROS-activatable prodrug 1 in main cardiomyocytes demonstrates security against peroxide-mediated poisoning and improves viability following simulated
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