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Recommendations are made for improving the control points in the industrial process and to avoid potential microbiological problems. Atopic dermatitis (AD) is a chronic, recurrent, inflammatory skin disease with an unmet need for treatments that provide rapid and high levels of skin clearance and itch improvement. To assess the safety and efficacy of upadacitinib vs dupilumab in adults with moderate-to-severe AD. Heads Up was a 24-week, head-to-head, phase 3b, multicenter, randomized, double-blinded, double-dummy, active-controlled clinical trial comparing