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Coumaplatin collects extremely effectively into the nucleoli, and upon photoactivation, this prodrug shows an even of photocytotoxicity as much as 2 sales of magnitude more than compared to oxaliplatin. Unexpectedly, this prodrug provides strikingly improved tumefaction penetration capability and makes use of a definite activity mode to conquer medicine resistance; for example., coumaplatin but not oxaliplatin induces cell senescence, p53-independent cell demi