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How a VC Can Affect Your Heart PVCs are common and may be experienced by a variety of people without causing any issues. If they occur regularly, PVCs can weaken your heart muscle and increase your risk of heart failure. The heart's rhythm is usually controlled by a group of fibers located in the upper right-hand part of your heart. This is called the sinoatrial node, or SA. Electrical signals travel to ventricles or lower chambers of your heart. Causes PVCs happen when the electrical impulse that usually begins your heart
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