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Atrial fibrillation (AF) may be the leading cause of ischemic stroke. Preventive antithrombotic use, particularly for anticoagulation, reduces the incidence of ischemic stroke in patients with AF. Utilizing information through the nationwide multicenter stroke registry, we investigated the styles of preceding antithrombotic medication used in patients with severe ischemic swing (AIS) with AF as well as its organization with preliminary stroke seriousness and in-hospital results. This research included 6786