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In inclusion, no significant long-term poisoning of PEG-TiO1+x NRs was discovered for the addressed mice. This work highlights a brand new kind of titanium-based nanostructure with great overall performance for tumor SDT.Ten new cassane diterpenoids, caesalpulcherrins A-J (1-1, along with 11 recognized analogues (11-21) had been separated through the aerial parts of Caesalpinia pulcherrima. Their structures and general stereochemistry had been elucidated by spectrometric and spectroscopic